文章基本信息

标题：A prospective evaluation of 200 upper endoscopies performed in Alaska Native persons
本地全文：下载
作者：Frank Sacco ; Michael G. Bruce ; Brian J. McMahon 等
期刊名称：International Journal of Circumpolar Health
印刷版ISSN：1239-9736
电子版ISSN：2242-3982
出版年度：2007
卷号：66
期号：2
DOI：10.3402/ijch.v66i2.18245
语种：English
摘要：OBJECTIVES: To characterize the nature and prevalence of disease in Alaska Native patients referred for evaluation of upper gastrointestinal signs and symptoms. STUDY DESIGN: Cross-sectional. METHODS: Two hundred consecutive Alaska Native patients referred to a statewide tertiary center were prospectively evaluated. A standardized data collection form documenting EGD findings was utilized. Routine biopsies of the antrum and fundus were taken on all patients. Additional tissue was obtained from any areas of clinical concern. RESULTS: Among 200 patients who underwent EGD during the study period, 130 (65%) tested H. pylori-positive on histology. Among 173 patients with histologic evidence of gastritis, 114 (66%) tested H. pylori-positive on histology. Chronic gastritis (87%), gastric ulcer (GU 12%), duodenal ulcer (DU 3%) and gastric cancer (2%) were the predominant findings. The GU:DU ratio was 4:1, the inverse of that reported in the general U.S. population. CONCLUSIONS: Alaska Native patients referred for upper endoscopy have a high rate of H. pylori infection with predominantly gastric manifestations of disease and a GU:DU ratio, which is the inverse of what is typically seen in the U.S. and other developed countries. The high prevalence of H. pylori in Alaska Native patients resembles prevalence patterns reported from developing countries and may be linked to a rate of gastric cancer that is over three times that found in the U.S. population at large.Keywords: Alaska Native; endoscopy; gastric cancer; gastritis,; Helicobacter pylori; ulcer(Int J Circumpolar Health 2007; 66(2):144-152)
关键词：Alaska Native; endoscopy; gastric cancer; gastritis,; Helicobacter pylori; ulcer