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标题：The association between n-3 fatty acids in erythrocyte membranes and insulin resistance: The inuit health in transition study
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作者：Trine Thorseng ; Daniel R. Witte ; Dorte Vistisen 等
期刊名称：International Journal of Circumpolar Health
印刷版ISSN：1239-9736
电子版ISSN：2242-3982
出版年度：2009
卷号：68
期号：4
DOI：10.3402/ijch.v68i4.17373
语种：English
摘要：Objectives. To examine the association between the content of n-3 fatty acids and insulin resistance in an Inuit population. Study design. The Inuit Health in Transition Study was carried out between 2003 and 2007 in Greenland as a cross-sectional study. Our preliminary results are based on the first 452 participants aged 18 and above. Only participants with at least 1 Inuit grandparent and without diabetes were included. Methods. The contents of n-3 fatty acids and the n-3/n-6 ratio were measured in the erythrocyte membrane phospholipids. BMI was calculated and questions concerning diabetes and ethnicity were answered. Insulin resistance was estimated using the HOMA-IR index based on fastingglucose and fasting-insulin. Results. We found an inverse association between C20:5 n- 3 (EPA), C22:3 n-3, the n-3/n-6 ratio and HOMA-IR and a positive association between C18:3 n-3 cis and HOMA-IR. When adjusted for age, gender, BMI and ethnicity, the association remained statistically significant for C20:5 n-3 (EPA), C22:3 n-3 and C18:3 n-3 cis. Conclusions. Our findings suggest that some types of n-3 fatty acids may have a protective effect against insulin resistance. The role of potential confounders such as physical activity, diet, energy intake, socio-economic status and contaminants deserves further exploration.(Int J Circumpolar Health 2009; 68(4):327-336)Keywords: n-3 fatty acids, insulin resistance, Greenland
关键词：n-3 fatty acids, insulin resistance, Greenland