文章基本信息

标题：Dead or alive: animal sampling during Ebola hemorrhagic fever outbreaks in humans
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作者：Sarah H. Olson ; Patricia Reed ; Kenneth N. Cameron 等
期刊名称：Emerging Health Threats Journal
印刷版ISSN：1752-8550
出版年度：2012
卷号：5
期号：0
DOI：10.3402/ehtj.v5i0.9134
语种：English
出版社：Emerging Health Threats Journal
摘要：There are currently no widely accepted animal surveillance guidelines for human Ebola hemorrhagic fever (EHF) outbreak investigations to identify potential sources of Ebolavirus (EBOV) spillover into humans and other animals. Animal field surveillance during and following an outbreak has several purposes, from helping identify the specific animal source of a human case to guiding control activities by describing the spatial and temporal distribution of wild circulating EBOV, informing public health efforts, and contributing to broader EHF research questions. Since 1976, researchers have sampled over 10,000 individual vertebrates from areas associated with human EHF outbreaks and tested for EBOV or antibodies. Using field surveillance data associated with EHF outbreaks, this review provides guidance on animal sampling for resource-limited outbreak situations, target species, and in some cases which diagnostics should be prioritized to rapidly assess the presence of EBOV in animal reservoirs. In brief, EBOV detection was 32.7% (18/55) for carcasses (animals found dead) and 0.2% (13/5309) for live captured animals. Our review indicates that for the purposes of identifying potential sources of transmission from animals to humans and isolating suspected virus in an animal in outbreak situations, (1) surveillance of free-ranging non-human primate mortality and morbidity should be a priority, (2) any wildlife morbidity or mortality events should be investigated and may hold the most promise for locating virus or viral genome sequences, (3) surveillance of some bat species is worthwhile to isolate and detect evidence of exposure, and (4) morbidity, mortality, and serology studies of domestic animals should prioritize dogs and pigs and include testing for virus and previous exposure.Keywords: ebolavirus; disease outbreaks; veterinarians; ecology; vertebrates; epidemiology(Published: 30 April 2012)Citation: Emerg Health Threats J 2012, 5: 9134 - http://dx.doi.org/10.3402/ehtj.v5i0.9134 To access the supplementary material to this article: Appendix A, B and C, please see Supplementary files in the column to the right (under Article Tools).
关键词：Surveillance; Wildlife health; Emerging Infectious Diseases;Ebolavirus; disease outbreaks; veterinarians; ecology; vertebrates; and epidemiology;Public aspects of medicine