文章基本信息

标题：Effects of a New Pyridone Carboxylic Acid Antibacterial Agent, Sparfloxacin, on Normal Human Intestinal Microflora
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作者：J. Watabe ; J. Mizutani ; H. Suzuki 等
期刊名称：Microbial Ecology in Health and Disease
印刷版ISSN：1651-2235
出版年度：1991
卷号：4
期号：5
DOI：10.3402/mehd.v4i5.7709
语种：English
出版社：Microbial Ecology in Health and Disease
摘要：The effects of a newly developed pyridone carboxylic acid antibacterial agent, sparfloxacin, on intestinal microflora were investigated in six healthy male volunteers. Sparffoxacin was given orally in two doses of 200 mg each with a 12 h interval, for 7 d. Members of the family Enterobacteriaceae and streptococci including enterococci in the faecal flora were suppressed markedly during spariloxacin treatment. Sparfloxacin did not decrease the level of anaerobic bacteria except for fusobacteria veillonella and Clostridium perfringens. Sparfloxacin had little effect on the overall levels of total bacteria in the intestine.Keywords: Antibacterial agent; Pyridone carboxylic acid; Spafioxacin; Intestinal flora.