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标题：Alternative Animal Models of Clostridium spiroforme Mediated Diarrhoea of Rabbits
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作者：R. J. Carman ; S. P. Borriello
期刊名称：Microbial Ecology in Health and Disease
印刷版ISSN：1651-2235
出版年度：1989
卷号：2
期号：1
DOI：10.3402/mehd.v2i1.7435
语种：English
出版社：Microbial Ecology in Health and Disease
摘要：Hamsters, guinea pigs, rats, mice and chickens were tested for their susceptibility to colonisation by, and subsequent pathogenicity of, Clostridium spiroforme. Only animals receiving both clindamycin and C. spiroforme presented with scours. These animals had both the bacterium and its toxin in their intestinal contents. Hamsters and guinea pigs were both consistently colonised and died within about 24 and 28 h respectively, following challenge. Mice and rats showed variable susceptibility, while chickens were consistently refractory to challenge.Keywords: Clostridium spiroforme; Animal model; Diarrhoea; Enterotoxaemia; Rabbit