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标题：Steroid Metabolising Enzymes of Clostridia: A Characteristic for the Strain or the Species?
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作者：V. D. Bokkenheuser ; M. Motyl ; K. Van Horn 等
期刊名称：Microbial Ecology in Health and Disease
印刷版ISSN：1651-2235
出版年度：1989
卷号：2
期号：4
DOI：10.3402/mehd.v2i4.7472
语种：English
出版社：Microbial Ecology in Health and Disease
摘要：In recent years, strains of different Clostridia species capable of metabolising steroids have been isolated from human faecal flora and from sewage. The organisms (enzymes) are C. cadaveris (20β-reductase and C17-20 desmolase); C. sporogenes (C21-hydroxy-acetylase); C. paraputrificum (3α-hydroxy-5β-reductase, chemically known as hydroxy steroid dehydrogenase, HSDH) and C. innocuum (3β,5β-HSDH). Examination of type and stock culture strains from different sources demonstrated that synthesis of steroid metabolising enzymes was characteristic for the species. Of sixteen type/neotype strains not previously reported to synthesise steroid active enzymes, fourteen produced a C21 hydroxy acetylase, and two, C. glycolicum and C. carnis, a 3α, 5β-HSDH.Keywords: Clostridia; Enzymatic markers; Species specificity; Steroid metabolising enzymes.