文章基本信息

标题：Effect of Olestra Upon Intestinal Microecology as Reflected by Five Microflora Associated Characteristics in Man
本地全文：下载
作者：U. Siigur ; K. E. Norin ; G. Allgood 等
期刊名称：Microbial Ecology in Health and Disease
印刷版ISSN：1651-2235
出版年度：1996
卷号：9
期号：6
DOI：10.3402/mehd.v9i6.8386
语种：English
出版社：Microbial Ecology in Health and Disease
摘要：To determine the effect of olestra on microbial ecology of the gut five microflora associated characteristics (MACs) were assessed in 93 subjects in a 36 d parallel, placebo-controlled, double-blind study. Degradation of tryptic activity, β-aspartylglycine and mucin, and conversion of cholesterol to coprostanol and bilirubin to urobilinogen were determined in faecal samples collected at the end of an 8 d low fibre baseline period and 28 d treatment period. The test meal consisted of either a moderate (7 g) or high (24 g) level of fibre and olestra (24 g) or an equivalent amount of conventional fat. Olestra had no effect on degradation of tryptic activity or β-aspartylglycine, and no consistent effect on mucin degradation. Olestra reduced significantly the conversion of cholesterol to coprostanol and urobilin to urobilinogen although the individual values were all within the range of healthy population after treatment. The lipophilic nature of cholesterol and urobilin is the most likely reason for the findings, as parts of the substrates partition into olestra and are not available to microorganisms.Keywords: olestra, faeces, microbial ecology, MACs.