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标题：Porphyromonas gingivalis: Presence of a Species-specific Antigen which is Discriminatory in Chronic Inflammatory Adult Periodontal Disease
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作者：A. J. Duncan ; R. J. Carman ; F. H. Harper 等
期刊名称：Microbial Ecology in Health and Disease
印刷版ISSN：1651-2235
出版年度：1992
卷号：5
期号：1
DOI：10.3402/mehd.v5i1.7762
语种：English
出版社：Microbial Ecology in Health and Disease
摘要：Serum from adults with and without evidence of past periodontitis was assayed for the presence of antibodies to outer membrane components of Porphyromonas gingivalis. A protein of 47 000 Da in Sarcosyl-insoluble outer membrane preparations was shown to be a discriminatory antigen insofar as serum from 29 of 31 (94 per cent) patients with a history ofchronic adult periodontitis contained immunoglobulin G antibodies against this protein compared to four of 24 (17 per cent) serum samples from individuals without disease. The binding of antibodies to this antigen was shown to be F(ab’)2 mediated. Type and reference strains of other oral and intestinal anaerobic bacteria were studied to see if the immunoreactive protein of 47 000 Da was exclusive to this species. None of the other microorganisms tested possessed this antigen, indicating that it is specific to P. gingivalis.Keywords: Porphyromonas gingivalis; Bacteroides gingivalis; Periodontal disease.