文章基本信息

标题：Treatment for Sulphur Mustard Poisoning -A Review
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作者：K. Sugendran ; Pravin Kumar ; R. Vijayaraghavan 等
期刊名称：Defence Science Journal
印刷版ISSN：0976-464X
出版年度：2013
卷号：48
期号：2
页码：155-162
DOI：10.14429/dsj.48.3894
语种：English
出版社：Defence Scientific Information & Documentation Centre
摘要：Sulphur mustard (SM) is a chemical warfare agent of historical and current interest It is a wellknown blistering agent or vesicant SM was extensively used in world war I as a chemical weaponand has been stockpiled by several counbies since that time. SM serves as an ideal war gas and is favoured militarily for its ability to incapacitate rather than to kill. Its use resulted in large numbers ofcasualties requiring prolonged and intensive medical care. Despite Geneva Protocol of 1925, which categorically bnned the production, stockpiling and use of chemical weapons in wars, SM has beenused in several wars, including the Iran-Irnq war during the 1980s, which renewed interest in it.Though, the chemical we'dpons convention was signed by more than 160 counbies in 1993 and wassubsequently ratified by several counbies, the threat from this agent persists due to its clandestineusage during war and also by teITOrist groups. There is no effective and specific antidote for local andsystemic toxicity of SM despite scientific research for more than 75 years. Many compounds weretested as antidotes for SM, but very few of them have been shown to provide some protection. The present review is aimed at evaluating the treatment regime and other clinical measures used to treat SM victims and the various drugs and chemicals screened as antidotes for SM poisoning in experimental animals.
关键词：Antidotes ;Treatment regime;Systemic toxicity;Chemical weapons;Geneva protocol;Intensive medical care