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标题：Sono-vigília, aspectos de memória e melatonina em Síndrome de Williams-Beuren: uma revisão de literatura
其他标题：Sleep-wake, aspects of memory and melatonin in Williams-Beuren syndrome: a review of literature
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作者：Santoro, Stella Donadon ; Pinato, Luciana
期刊名称：Revista CEFAC
印刷版ISSN：1516-1846
电子版ISSN：1982-0216
出版年度：2014
卷号：16
期号：6
页码：1980-1989
DOI：10.1590/1982-0216201417113
出版社：CEFAC Saúde e Educação
摘要：The Williams-Beuren syndrome, a genetic disorder (microdeletion in chromossome region 7q11.23) presents an apparent social skills with contrasts with the low global cognitive performance and visuospatial problems as receptive, structural and semantic form of communication, besides deficits in attention, hyperactivity and memory impairments in visuospatial. Another feature are disorders of the sleep-wake cycle with sleep ineffective resistance to going to bed, wake up at night and drowsiness during the day. A possibility not yet explored would be the abnormal pattern in the synthesis of melatonin, a hormone that can modulate the quality of sleep. Considering the assumption that the quality of sleep is directly influenced by the levels of melatonin and essential for the proper development of cognitive functions, sought to in this literature review which studies that investigated separately and correlated these three aspects or in Williams-Beuren syndrome: sleep-wake, memory and melatonin. To search, was used Medline/Pubmed, SciELO and Lilacs databases, with the keywords: “Williams Beuren syndrome, síndrome de Williams Beuren, memory, memória, sleep-wake, sono-vigília, melatonin e melatonina” for means of crossing and the AND connective. The literature review showed that there are no jobs that these three variables correlate with each other nor work to investigate melatonin in Williams-Beuren syndrome. The individual investigations on sleep and memory are critically discussed in this work that emphasizes the need for studies to correlate these parameters, as well as behavioral, cognitive and biochemical related to them.
关键词：Sono;Vigília;Memória;Melatonina;Síndrome de Williams;Deficiências do Desenvolvimento
其他关键词：Sleep;Wakefulness;Memory;Melatonin;Williams-Beuren syndrome;Developmental Disabilities