The relevance of the problem stems from the fact that the implementation of the cluster approach in the regional system of vocational education aimed at the maintenance and development of joint potential opportunities of industrial and educational spheres, which create prospects for progressive development of the Tatarstan Republic. This article aims to identify the features of the cluster approach in the regional system of vocational training that focus on strengthening the relationship network between the cluster members in order to facilitate access to new industrial and educational technologies, to share knowledge and fixed-capital assets, to accelerate learning processes due to continuity and integration processes in a single integrated regional educational-industrial complex. The article stuff is valuable for managers of vocational training institutions and representatives of the industrial sector in order to prepare specialists meeting the requirements of modern production.