The aim of the present investigation was to describe and to analyze the relationship between negative evens life experienced and perceived quality of life in adolescents. The participants were 364 adolescents living in the Algarve (55,5% girls, 44,5% boys), aged between 12 and 18 years. We used The Stressful Life Events Questionnaire and the Kidscreen-52 for children and adolescents, and a Socio-demographic Data Questionnaire. Negative life events more frequent were change of classmates (46,72%), death of a family member (34,97%), change of school (30,05%), fights (28,69%) and illness of a family member (28,69%). Boys reported to suffer more stressful life events than girls; however its emotional impact was higher for girls. Positive significant correlations were found between the number of negative life events and the quality of life, except for Health and Activity, Friends and Provocation. The emotional impact of negative life events was positively associated only with the subscales Feelings, About Yourself and Total Quality of Life. No differences were found between boys and girls in Quality of Life, except for relationships with Friends, with higher scores reported by girls.