The aim of this paper is to discuss, in an interdisciplinary way, the necessary conditions and steps to achieve a more autonomous political and economic model on the world stage for South America countries. It departs from the political and social conditions of the region by the end of the first decade of this century. Emphasis is placed on the role of Brazil across the region in the light of the economic and political relations in the international arena, political stability and the growing influence of China. It also examines issues concerning the importance of maintaining an inclusive social policy and a common defense policy under the Southern America Nations Union (Unasur).