The aim of this observational study was to estimate the survival function and risk of death in Botucatu, Southeast Brazil, by occupation. The occupational history of inhabitants of Botucatu who died after their 10th birthday from January 1, 1997, to March 31, 1998, was analyzed, as were the occupational histories of workers' spouses. A total of 992 subjects were studied. Data were analyzed by fitting a proportional hazards model where the time variable was age at death or at time of interview and the main co-variable was occupation. Results showed that risk of death increased consistently as the level of occupational specialization decreased, displaying a 12-year increase in life expectancy for professional as compared to unskilled workers.