This article reflects on the theoretical and practical foundations impacting and shaping the field of workers' health in Brazil, as part of the overall field of collective health. By analyzing the various forms of approaching the relationship between work and health, the paper emphasizes its complex and conflicting nature as a central reference for the work process, in keeping with the premises of social medicine in Latin America. This focus underscores the need for interdisciplinary approaches contemplating and even extrapolating the links between areas of knowledge generally ascribed to the field of health. Finally, the paper gives a brief diagnosis of the current situation in this field, where pending questions join those resulting from globalization of the economy and particularly industrial restructuring, in light of which the challenge is raised to broaden the objects of study and intervention to include the implications of outsourcing, increasingly precarious labor conditions, informal labor, and unemployment on the population's health and living conditions.