文章基本信息

标题：Stimulation frequency determines the distribution of language positive cortical regions during navigated transcranial magnetic brain stimulation
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作者：Theresa Hauck ; Noriko Tanigawa ; Monika Probst 等
期刊名称：BMC Neuroscience
印刷版ISSN：1471-2202
电子版ISSN：1471-2202
出版年度：2015
卷号：16
期号：1
页码：1
DOI：10.1186/s12868-015-0143-9
语种：English
出版社：BioMed Central
摘要：Background Although language mapping by repetitive navigated transcranial magnetic stimulation (rTMS) gains importance in neuropsychological research and clinical utility, neuroscientists still use different mapping protocols including different stimulation frequencies. To refine the existing language protocol, we tested two different repetition rates of 5 Hz/10 pulses and 7 Hz/10 pulses with a 0 ms delay in 19 healthy subjects. We furthermore investigated differences between both frequencies in case of performance of four different language tasks: object naming, pseudoword reading, verb generation, and action naming. Results Even the small variance in frequencies revealed statistically significant differences concerning the number and type of language errors. Stimulation with 5 Hz evoked a higher number of all occurred language errors in all language tasks (error rate object naming 14% (5 Hz) vs. 12% (7 Hz); pseudoword reading 4% (5 Hz) vs. 3% (7 Hz); verb generation 13% (5 Hz) vs. 11% (7 Hz); action naming 11% (5 Hz) vs. 9% (7 Hz)), whereas 7 Hz evoked specifically more total speech arrests. Conclusion These findings suggest that the stimulation frequency has to be adapted to the aim of the rTMS language investigation.
关键词：Action naming ; Cortical mapping ; Frequency ; Mapping protocol ; Navigated brain stimulation ; Object naming ; Pseudoword reading ; Transcranial magnetic stimulation ; Verb generation