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标题：Effect of Sodium Iron EDTA Fortification in Tempe in Serum Iron and Ferritin Level of Anemic Female Wistar Rats
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作者：Toto Sudargo ; Rio Jati Kusuma ; Tonny Arjuna 等
期刊名称：Pakistan Journal of Nutrition
印刷版ISSN：1680-5194
电子版ISSN：1994-7984
出版年度：2015
卷号：14
期号：2
页码：88-93
DOI：10.3923/pjn.2015.88.93
出版社：Asian Network for Scientific Information
摘要：In Indonesia, the prevalence of iron deficiency anemia is still high. Iron fortification in food using sodium ferry EDTA (NaFeEDTA) potentially reduce the incidence of iron deficiency anemia. Iron deficient anemia was induced in female Wistar rats by feeding low iron (Fe) diet and was randomly divided into ten groups where one group was fed normal diet which serves as control group. Every treatment group will receive FeSO₄, tempe and iron-fortified tempe (temFe) with iron dosage of 6, 12 and 24 ppm respectively for 17 days. Blood was drawn for serum iron (SI) and serum ferritin (SF) measurement. After treatment, temFe 24 ppm group has the highest SI and the highest SI changed compared with other treatment groups although no significant different (p>0.05) was observed between temFe 24 ppm group and FeSO₄ 24 ppm group for SI (139.36±1.58 vs 134.10±2.73 μg/dL) and SI changed (89.40±2.78 vs 84.47±2.41 μg/dL). SF was increased in all treatment diet with the highest was found in FeSO₄ 24 ppm group (73.25±3.16 ng/mL). However, SF level wasnt significantly different between the FeSO₄ 24 ppm, tempe 24 ppm and temFe 24 ppm and group (p>0.05). Iron fortification in tempe with NaFeEDTA will restore both SI and SF in iron deficiency anemia.