文章基本信息

标题：Systematic review and meta-analysis of prospective studies for ECP treatment in patients with steroid-refractory acute GVHD
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作者：Hongming Zhang ; Runzhe Chen ; Jian Cheng 等
期刊名称：Patient Preference and Adherence
印刷版ISSN：1177-889X
电子版ISSN：1177-889X
出版年度：2015
卷号：9
页码：105-111
DOI：10.2147/PPA.S76563
出版社：Dove Medical Press Ltd
摘要：Purpose: The aim of this systematic review was to evaluate the efficacy and safety of extracorporeal photopheresis (ECP) treatment in patients with steroid-refractory acute graft-versus-host disease (SR-aGVHD). Methods: An electronic search was carried out on the MEDLINE, EMBASE, Science Citation Index (SCI), and Cochrane Library databases. We included prospective clinical trials in SR-aGVHD treated by ECP. The main endpoints consisted of mortality, exacerbation, or response. Results: Only seven studies involving 121 patients met the inclusion criteria for further review. Our analysis showed positive results of ECP for aGVHD. The overall response rate (ORR) was 0.71 and the complete response rate (CRR) was 0.71. The efficacy of ECP for skin aGVHD, liver aGVHD, and gut aGVHD were 0.86, 0.60, and 0.68, respectively. However, no sufficient evidence verifies the exact benefit in this review, because the number of patients enrolled in trials is limited and publish bias exists. Conclusion: ECP is an effective therapy for skin, liver, and gut aGVHD, and large double-blind clinical trials are required to prove the outcome of this meta-analysis.
关键词：extracorporeal photopheresis; steroid-refractory acute graft-versus-host disease; allogeneic hematopoietic stem cell transplantation