文章基本信息

标题：Identifying strains that contribute to complex diseases through the study of microbial inheritance
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作者：Jeremiah J. Faith ; Jean-Frédéric Colombel ; Jeffrey I. Gordon 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2015
卷号：112
期号：3
页码：633-640
DOI：10.1073/pnas.1418781112
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：It has been 35 y since Carl Woese reported in PNAS how sequencing ribosomal RNA genes could be used to distinguish the three domains of life on Earth. During the past decade, 16S rDNA sequencing has enabled the now frequent enumeration of bacterial communities that populate the bodies of humans representing different ages, cultural traditions, and health states. A challenge going forward is to quantify the contributions of community members to wellness, disease risk, and disease pathogenesis. Here, we explore a theoretical framework for studies of the inheritance of bacterial strains and discuss the advantages and disadvantages of various study designs for assessing the contribution of strains to complex diseases.
关键词：microbial inheritance ; strain-resolution human microbial ecology analyses ; effector strains ; health ; disease