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标题：Alcohol-related neuropsychological deficits: an explanation of relapse?
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作者：Hélène Beaunieux ; Ludivine Ritz ; Shailendra Segobin 等
期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2013
卷号：5
期号：3
页码：159-165
DOI：10.1684/nrp.2013.0268
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Hélène Beaunieux , Ludivine Ritz , Shailendra Segobin , Anne-Pascale Le Berre , Coralie Lannuzel , Céline Boudehent , François Vabret , Francis Eustache , Anne-Lise Pitel Inserm, EPHE, Université Caen - Basse-Normandie, CHU de Caen, GIP Cyceron, unité U1077, boulevard Becquerel, BP 5229, 14074 Caen cedex, France Key words: alcohol-dependence, executive functions, episodic memory, relapse DOI : 10.1684/nrp.2013.0268 Page(s) : 159-65 Published in: 2013 Chronic and excessive alcohol consumption can result in structural and functional brain abnormalities mainly affecting the frontocerebellar circuit and the circuit of Papez in alcoholic patients. When present, those brain damages are associated with graded neuropsychological deficits such as deficits of executive functions, episodic memory and emotional processes. The contribution of these neuropsychological deficits to relapse has been investigated in cross-sectional and longitudinal studies. Cross-sectional studies show that impairments of executive functions and episodic memory may reduce the benefit of motivational therapy and behavioral treatment. Longitudinal studies suggest that, among other factors, several neuropsychological deficits may contribute to relapse. Further longitudinal studies are required to provide a better understanding of the role of brain damage and neuropsychological deficits in relapse. Those factors will have to be explored in combination with social or environmental variables to improve the detection of alcoholics at risk for relapse.
关键词：alcohol-dependence; executive functions; episodic memory; relapse