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标题：Time-course and qualitative analysis of unconstrained oral naming abilities in non-demented Parkinson's individuals
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作者：Christina Tremblay ; Jessica Blais ; Jeanne Lachance 等
期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2010
卷号：2
期号：4
页码：273-282
DOI：10.1684/nrp.2010.0083
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Christina Tremblay , Jessica Blais , Jeanne Lachance , Alain Ptito , Oury Monchi , Laura Monetta Département de Réadaptation, Faculté de médecine de l'Université Laval, Québec, Centre de recherche de l'Institut Universitaire en Santé mentale de Québec Robert-Giffard, Québec, Centre de Recherche de l'Institut Universitaire de Montréal, Département de Radiologie, Université de Montréal, Montréal, Montreal Neurological Institute and McGill University Health Centre, Montréal, Canada Key words: Parkinson's disease, oral naming test, verbal fluency, language impairment, executive processes DOI : 10.1684/nrp.2010.0083 Page(s) : 273-82 Published in: 2010 The goal of this study was to provide a quantitative and qualitative analysis of the word production of patients with Parkinson's disease (PD) and compare it to that of matched control individuals, with an emphasis on the characteristics of the words produced and their correlation with the presence of executive deficits. Semantic and phonological oral naming tests (ONT) are often used to assess cognitive dysfunction in PD. In general, results have shown that patients with PD produce fewer words in both tasks than matched control individuals while the qualitative analyses of word production in PD patients are contradictory. While some studies have shown that the average size of phonemic and semantic clusters are not reduced in PD, others have reported that switching and clustering are decreased in PD patients. These contradictory results could be partially explained by the different evaluation criteria used (semantic and phonologic). In order to minimize this factor, we used an unconstrained oral naming task (UON) where a group of non-demented PD and a group of control individuals, matched for gender, age and education, were invited to produce words within a limited time period (150 second), without having to respect any production criterion. Different aspects of word production were analyzed, such as number of words, frequency, familiarity, concreteness and number of words produced within each 30-second period. Participants also performed a short neuropsychological battery and analysis production was correlated with their profile. Results showed that switching is impaired in PD patients while clustering is not. The results of this qualitative analysis are consistent with the possibility that the oral naming production of Parkinson's patients reflects a disruption of frontal-basal ganglia circuits mediating set-shifting abilities.
关键词：Parkinson's disease; oral naming test; verbal fluency; language impairment; executive processes