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标题：Lexico-semantic alteration in Alzheimer’s disease and semantic dementia through the prism of semantic priming effects
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作者：Mickaël Laisney ; Béatrice Desgranges ; Francis Eustache 等
期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2010
卷号：2
期号：1
页码：46-54
DOI：10.1684/nrp.2009.0054
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Mickaël Laisney , Béatrice Desgranges , Francis Eustache , Bénédicte Giffard Unité U923, Inserm – EPHE – Université de Caen/Basse-Normandie, Caen Key words: semantic dementia, priming effects, emotions, Alzheimer’s disease, semantic memory DOI : 10.1684/nrp.2009.0054 Page(s) : 46-54 Published in: 2010 Priming paradigms depend on implicit memory, so do not rely on other non-semantic processes. Thus, they allow a very pure and sharp measure of semantic memory and also constitute a relevant methodology to explore the structure of the semantic network. Consequently, many studies have examined semantic priming effects produced by patients suffering from neurodegenerative diseases. They allow a better understanding of cognitive deficits in these pathologies and also bring interesting data about semantic memory models. The current paper deals with semantic deficits in two dementia syndromes – Alzheimer’s disease and semantic dementia – through semantic priming effects. In Alzheimer disease, the first studies focused on the issue of the nature of the semantic memory disorders, ending in the characterization of the dynamic of the semantic memory degradation. Neuroimaging studies provide another approach offering new insights about semantic deficits in Alzheimer’s disease. Recently, studies on semantic priming have included emotionally loaded concepts. Despite their small number, studies of semantic priming effects in semantic dementia made a significant contribution to the debate about the organisation of the semantic network. Direct comparison between Alzheimer’s disease and semantic dementia will be described, which is rarely done in the literature. Finally, despite their usefulness, semantic priming paradigms require an unwieldy methodology hardly compatible with the daily neuropsychological practice. However, considering the relative preservation of implicit memory in neurodegenerative diseases, they could be adapted to the cognitive rehabilitation.
关键词：semantic dementia; priming effects; emotions; Alzheimer’s disease; semantic memory