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标题：Neglect syndrome: from clinical polymorphism to therapeutic polymorphism
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作者：Sophie Jacquin-Courtois ; Gilles Rode ; Jacques Luauté 等
期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2009
卷号：1
期号：4
页码：332-336
DOI：10.1684/nrp.2009.0038
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Sophie Jacquin-Courtois , Gilles Rode , Jacques Luauté , Laure Pisella , Alessandro Farne , Jacintha O’Shea , Dominique Boisson , Yves Rossetti Université de Lyon-I, Inserm UMR-S 864, 16, avenue du Doyen-Lépine, 69676 Bron cedex, France, Hospices civils de Lyon, 3, quai des Celestins, BP 2251, 69229 Lyon cedex 02, France, Service de médecine physique et réadaptation, hôpital Henry-Gabrielle, 20, route de Vourles, 69230 Saint-Genis Laval, France, Oxford Centre for functional MRI of the Brain (FMRIB), John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, Angleterre Key words: unilateral neglect, spatial cognition, rehabilitation, sensori-motor plasticity DOI : 10.1684/nrp.2009.0038 Page(s) : 332-6 Published in: 2009 Unilateral neglect is a neurological deficit of utilization and consciousness of space, frequently occurring after right brain damage, in particular in case of parietal damage. Neglect is a multi-component syndrome, but its defining feature is that patients fail to voluntarily attend to, or to act in, the opposite (left) half of space or of the body. Polymorphism and complexity take also place in terms of physiopathological mechanisms, with possible combination of spatially lateralized processes (attention, representation) and non lateralized processes (attention, spatial working memory, remapping). This peculiar neurological disorder induces many functional debilitating effects on everyday life, and is responsible for poor functional recovery. It appears thus relevant to assess precisely this deficit and it underlines the importance of therapeutic stake. Many different therapeutic methods have been developed, initially based on intention and conscious effort (“top-down” approach). The more encouraging perspectives in terms of generalization and transfer are based on more automatic processes (“bottom-up”) involving sensory or vestibular stimulations, or mediated by after-effects induced by prism adaptation. Some additional methods are more recently experimented, in particular involving psychopharmacological process and centering on management of non lateralized attentional deficits. In the more recent years, cerebral transcranial stimulation tedchniques have been used to test the theorical proposal that neglect occurs because a unilateral stroke disrupts the normal balance of neural activity between the two hemispheres. This kind of approach seems to be promising in terms of therapeutic possibilities.
关键词：unilateral neglect; spatial cognition; rehabilitation; sensori-motor plasticity