文章基本信息

标题：Cortical plasticity in visual areas after a post-chiasmatic lesion: a neuro-imaging study
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作者：Céline Perez ; Céline Cavézian ; Carole Peyrin 等
期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2009
卷号：1
期号：3
页码：254-260
DOI：10.1684/nrp.2009.0036
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Céline Perez , Céline Cavézian , Carole Peyrin , Olivier Coubard , Gaëlle Doucet , Frédéric Andersson , Olivier Gout , Julien Savatovsky , Sylvie Chokron Laboratoire de psychologie et neurocognition, CNRS, UMR5105, UPMF, Grenoble, ERT TREAT VISION, Fondation ophtalmologique Rothschild, Paris, Service de neurologie, Fondation ophtalmologique Rothschild, Paris, CI-NAPS (centre d’imagerie-neurosciences et d’applications aux pathologies), UMR 6232, Caen, Université F.-Rabelais, Tours-IFR 135, Tours, Service de neuroradiologie, Fondation ophtalmologique Rothschild, Paris Key words: homonymous hemianopia, natural scenes, detection/categorization, fMRI, cortical plasticity DOI : 10.1684/nrp.2009.0036 Page(s) : 254-60 Published in: 2009 Imaging studies in patients with unilateral occipital damage show a cortical reorganization in the damaged hemisphere but also within the healthy hemisphere. Such reorganization appears to be underlain by a stronger hemispheric connectivity, especially between MT+/V5 areas and the lateral geniculate nuclei. Nevertheless, most of these studies did not investigate the effect of the lesion side on these reorganizations. In healthy participants, even a largely visual task (i.e. prompt to highlight a right hemisphere predominance) can reveal left hemisphere predominance. Altogether, the literature raises the question of interactions between lesion side, task, and cortical plasticity. The preliminary results of our fMRI study provide a few answers about these interactions. The cortical network underlying detection and categorization of natural scene images presented in the central visual field was investigated in one healthy participant, and two patients with an occipital lobe injury (either right or left). The control participant showed activation in the extrastriated occipital areas of both hemispheres during the detection task, but asymmetric left hemisphere activation during the categorization task. In patients, the activation seems to depend upon the lesion side. Regardless of the task, we observed a bilateral activation in the right brain damage patient (left hemianope) whereas in the left brain damage patient (right hemianope) the activation was mainly observed in the right hemisphere. Overall, these results suggest that the cortical reorganization in hemianopic patients may depend upon the occipital lesion side.
关键词：homonymous hemianopia; natural scenes; detection/categorization; fMRI; cortical plasticity