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标题：The questions of transient global amnesia
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作者：Peggy Quinette ; Audrey Noël ; Béatrice Desgranges 等
期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2009
卷号：1
期号：2
页码：170-174
DOI：10.1684/nrp.2009.0024
出版社：John Libbey Eurotext
摘要：Authors Peggy Quinette , Audrey Noël , Béatrice Desgranges , Vincent de La Sayette , Fausto Viader , Francis Eustache Inserm-EPHE-université de Caen/Basse-Normandie, Unité 923, GIP Cyceron, CHU Côte de Nacre, Caen, Service de neurologie, CHU Côte de Nacre, Caen Key words: transient global amnesia, episodic memory, episodic buffer, autonoetic consciousness, emotional state, hippocampus DOI : 10.1684/nrp.2009.0024 Page(s) : 170-4 Published in: 2009 This review of recent neuropsychological, psychopathological and neuroimaging data concerns a number of issues that remain elusive in transient global amnesia (TGA). Studies of anterograde amnesia carried out during the acute phase showed that patients were affected in the first stage of episodic memory encoding. The episodic memory failure was associated to a dysfunction of the episodic buffer, a newly described component of working memory, which could account for the deficits in the integration of multimodal information. In the light of the current definitions of episodic memory, the memory disorder of TGA patients is regarded as an impairment of autonoetic consciousness. During the acute phase, conscious awareness is altered, which affects the ability to mental time travel from the past through the future. An extensive investigation of psychopathological factors have found that TGA comprises sudden changes in emotional state (high level of anxiety and a more depressed mood) that were no more found in the recovery phase. The question of the origin of these psychopathological disorders remains unsettled. In keeping with robust neuropsychological evidence, recent imaging studies finally suggest that an acute and reversible dysfunction (the cause of which is unknown) of the hippocampus, and possibly other parts of Papez’s circuit, could be the cause of amnesia in the TGA syndrome.
关键词：transient global amnesia; episodic memory; episodic buffer; autonoetic consciousness; emotional state; hippocampus