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标题：Severe liver cytolysis could be a marker of the severity of hemorrhagic dengue: report of two cases
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作者：V. Guiyedi ; M. Mattei ; A. Sommabere 等
期刊名称：Médecine et Santé Tropicales
印刷版ISSN：1157-5999
电子版ISSN：1950-6953
出版年度：2012
卷号：22
期号：1
页码：87-90
DOI：10.1684/mst.2012.0014
出版社：John Libbey Eurotext
摘要：Authors V. Guiyedi , M. Mattei , A. Sommabere , E. Karam , J.B. Allard , Y. Regouby , M. Okome-Nkoumou , G. Lambert de Cursay , B.V. Abraham Service de médecine interne, rhumatologie, maladies infectieuses et tropicales,, Service de réanimation,, Laboratoire de microbiologie, immunohématologie et biochimie médicale, centre hospitalier de Brive-la-Gaillarde, France., Département des maladies infectieuses et tropicales, fondation Jeanne-Ebori, université des sciences de la santé, Libreville, Gabon. Key words: liver cytolysis, severity marker, dengue DOI : 10.1684/mst.2012.0014 Page(s) : 87-90 Published in: 2012 We report two cases of severe dengue fever in persons returned from stays in endemic areas during the summer outbreak of 2010. Both presented a hemorrhagic syndrome associated with primary hemostasis disorders, neutropenia, and severe hepatic cytolysis without any hepatocellular insufficiency. Three days after hospitalization, the first patient's AST and ALT levels rose to 80 and 12 times the upper reference values respectively, and the second patient's to 12 and 7 times those values. The second also presented signs of hemodynamic shock. Our observations suggest that the combination of severe hepatic cytolysis and hemostatic disorders may be a predictive marker of the severity of dengue fever. The pathophysiologic mechanisms explaining this severity remain unknown.
关键词：liver cytolysis; severity marker; dengue