文章基本信息

标题：Derivation of toxicological reference values for taking mixtures into account in health risk assessment: Existing methods and recent applications
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作者：Kevin Fournier ; Philippe Glorennec ; Nathalie Bonvallot 等
期刊名称：Environnement, Risques & Santé
印刷版ISSN：1635-0421
电子版ISSN：1952-3398
出版年度：2014
卷号：13
期号：3
页码：203-221
DOI：10.1684/ers.2014.0696
出版社：John Libbey Eurotext
摘要：Figures Tables Authors Kevin Fournier * Philippe Glorennec Nathalie Bonvallot EHESP Inserm U 1085 Avenue du Professeur Léon Bernard CS 74312 35043 Rennes cedex France * Tirés à part Key words: environmental pollutants, mixtures, risk assessment, toxicological reference values DOI : 10.1684/ers.2014.0696 Page(s) : 203-21 Published in: 2014 Human beings are exposed through their environment to numerous chemicals. Several approaches to cumulative risk assessment, including the sum of hazard quotients, toxic equivalent factors (TEF), and the point of departure index (PODI), have been developed to estimate the risks due to these exposures. Their principles are based on the assumption of effect or dose additivity, and their main purpose is to provide tools to help decision-makers in a context where uncertainty predominates. They also highlight the lack of adequate data, especially for toxicity data and dose-response relations. The objective of this article is to propose a brief history of these approaches and to describe their current applications through examples from the literature. While few institutional recommendations allow mixtures to be taken into account in cumulative risk assessment approaches, many approaches have been published in recent years. Although the development of TEFs requires precise knowledge about the toxic mechanisms of action, other approaches, less stringent in term of knowledge, have been developed and are already usable. This is the case for relative potency factors for pyrethroids, organophosphates, phthalates, and fungicides; or PODI for certain anti-androgens.
关键词：environmental pollutants; mixtures; risk assessment; toxicological reference values