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标题：Method for identifying and prioritizing the reprotoxic chemicals for which human toxicity values must be derived
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作者：Nathalie Bonvallot ; Jean-Ulrich Mullot ; Cécilia Solal 等
期刊名称：Environnement, Risques & Santé
印刷版ISSN：1635-0421
电子版ISSN：1952-3398
出版年度：2009
卷号：8
期号：2
页码：119-131
DOI：10.1684/ers.2009.0236
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Nathalie Bonvallot , Jean-Ulrich Mullot , Cécilia Solal , Frédéric Dor Agence française de sécurité sanitaire de l’environnement et du travail 253, avenue du Général-Leclerc 94701 Maisons-Alfort cedex France, Laboratoire d’analyses de surveillance et d’expertise de la marine (LASEM) de Toulon Base navale de Toulon, BP 61 83800 Toulon-Armées France, Institut de veille sanitaire, 12, rue du Val-d’Osne 94415 Saint-Maurice cedex France Key words: hazardous chemicals, health priorities, human toxicity values, ranking, reproduction, scoring DOI : 10.1684/ers.2009.0236 Page(s) : 119-31 Published in: 2009 Recent decades have witnessed rising concern about the impact of the environment and chemicals on human reproductive function. Semen quality has declined, and abnormalities of the reproductive tract have increased. Reprotoxic chemicals are currently of great interest to public authorities. The French Agency for Environmental and Occupational Health Safety (Afsset) proposed in 2004 to conduct an expert assessment to determine human toxicity values (HTVs) based on reprotoxic endpoints. One of the objectives was to identify chemicals with reprotoxic properties in order to set priorities for toxicological reviews and derivation of reprotoxic HTVs. A list of chemicals that are probably or likely reprotoxic was compiled, based on European regulatory classifications and other non-regulatory lists of reprotoxic chemicals: 445 substances were identified. We developed a method for prioritization, based on the relevance of the data sources and on the occurrence of the substances in the available priority lists. Each of the 445 substances was scored to take into account their potential hazards and exposure, as a simplified approach to the two essential parameters of risk assessment. The total score was calculated as the product of indirect hazard and exposure scores, weighted to produce a single scale of values. The chemicals of highest concern are some phthalates, metals, alkylphenols and glycol ethers. Scoring approaches are widely used to define priorities at regional, national and international levels. Despite the limitations identified, this method appears useful as a preliminary approach to the identification of chemicals for which additional studies should be conducted.
关键词：hazardous chemicals; health priorities; human toxicity values; ranking; reproduction; scoring