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标题：Hazard identification: Improving this stage of risk assessment
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作者：Frédéric Dor ; Nathalie Bonvallot
期刊名称：Environnement, Risques & Santé
印刷版ISSN：1635-0421
电子版ISSN：1952-3398
出版年度：2007
卷号：6
期号：4
页码：279-287
DOI：10.1684/ers.2007.0093
出版社：John Libbey Eurotext
摘要：Figures See all figures Authors Frédéric Dor , Nathalie Bonvallot Institut de veille sanitaire (InVS), 12, rue du Val d’Osne, 94415 Saint-Maurice cedex, Agence française de sécurité sanitaire de l’environnement et du travail (Afsset), 253, avenue du Général Leclerc, 94701 Maisons-Alfort cedex Key words: animal experimentation, dose-response relationship, hazard identification, health risk assessment, toxic actions, toxicological reference value DOI : 10.1684/ers.2007.0093 Page(s) : 279-87 Published in: 2007 The procedure for quantitative health risk assessments uses four systematic steps to organise available knowledge, identify the gaps and, when possible, assess the health risks in the exposed population. The four steps are: hazard identification, assessment of dose-response relations, exposure assessment and risk characterisation. This methodological development has led to the publication of a sizable body of scientific knowledge. Recent developments in toxicology include the identification of both effects and modes of action. Taking these into account and analysing the consistency of data from animal and epidemiological studies, we suggest structuring the hazard identification step to improve the choice of the toxicity reference value (TRV) and the interpretation of the risk assessment results. Some examples illustrate the importance of this consistency analysis and point out the interest in considering the entire dose-effect relation and not only the "critical effect" considered in deriving the TRV. This process would strengthen the interpretation of the public health implications of these assessments.
关键词：animal experimentation; dose-response relationship; hazard identification; health risk assessment; toxic actions; toxicological reference value