文章基本信息

标题：Integrated Statistical and Rule-Mining Techniques for Dna Methylation and Gene Expression Data Analysis
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作者：Saurav Mallik ; Anirban Mukhopadhyay ; Ujjwal Maulik 等
期刊名称：Journal of Artificial Intelligence and Soft Computing Research
电子版ISSN：2083-2567
出版年度：2013
卷号：3
期号：2
页码：101-115
DOI：10.2478/jaiscr-2014-0008
出版社：Walter de Gruyter GmbH
摘要：For determination of the relationships among significant gene markers, statistical analysis and association rule mining are considered as very useful protocols. The first protocol identifies the significant differentially expressed/methylated gene markers, whereas the second one produces the interesting relationships among them across different types of samples or conditions. In this article, statistical tests and association rule mining based approaches have been used on gene expression and DNA methylation datasets for the prediction of different classes of samples (viz., Uterine Leiomyoma/class-formersmoker and uterine myometrium/class-neversmoker). A novel rule-based classifier is proposed for this purpose. Depending on sixteen different rule-interestingness measures, we have utilized a Genetic Algorithm based rank aggregation technique on the association rules which are generated from the training set of data by Apriori association rule mining algorithm. After determining the ranks of the rules, we have conducted a majority voting technique on each test point to estimate its class-label through weighted-sum method. We have run this classifier on the combined dataset using 4-fold cross-validations, and thereafter a comparative performance analysis has been made with other popular rulebased classifiers. Finally, the status of some important gene markers has been identified through the frequency analysis in the evolved rules for the two class-labels individually to formulate the interesting associations among them.