文章基本信息

标题：Bovine colostrum as substrate for the preparation of growth factor-enriched protein extracts: Identifying the optimal collection period during lactation
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作者：Alicia Montoni ; Sylvie F. Gauthier ; Caroline Richard 等
期刊名称：Dairy Science & Technology
印刷版ISSN：1958-5586
电子版ISSN：1958-5594
出版年度：2009
卷号：89
期号：5
页码：511-518
DOI：10.1051/dst/2009028
语种：English
出版社：EDP Sciences
摘要：A growing number of growth factor-enriched bioactive protein extracts derived from colostrum are proposed for the treatment of inflammatory and cutaneous diseases. However, growth factor concentrations peak in the first secretions after parturition and vary widely among cows. The aim of this study was to identify the optimal collection period for colostrum used to prepare growth factor-enriched protein extracts and to characterize the relationship between growth factor and protein contents in colostrum and in milk collected during early lactation. Lacteal secretions from five Holstein cows from the first milking ($<$ 12 h) to the 21st day after parturition were analysed for total protein and growth factor (TGF-$\beta$2, TGF-$\beta$1 and IGF-I) contents. Although concentrations varied widely between cows, statistically significant decreases were obtained for all components during the early stages of lactation. The concentrations of each growth factor during lactation were highly correlated ($R$$^{2}$ > 0.93) and were also correlated with the total protein content ($R$$^{2}$ > 0.90). The greatest decreases in the concentrations of the three growth factors (78–84%) were observed within 24–48 h after parturition, while values stabilized in mature milk. However, relative to protein, these decreases appeared much smaller (37–45%). Overall, these results suggest that the first 48 h after parturition would be optimal for harvesting colostrum for the production of growth factor-enriched protein extracts.
关键词：bovine colostrum;bovine milk;growth factor;IFG-I;TGF-$\beta$1;TGF-$\beta$2;growth factor-enriched ingredient