The present study was performed to evaluate the surface roughness and effect of Tetracycline-HCl on the change of implant surface microstructure according to application time. TiO₂ surface Implant was utilized. Implant surface was rubbed with 50mg/ml Tetracycline-HCl solution for 0.5min, 1min, 1.5min, 2min, 2.5min and 3min respectively in the Tetracycline-HCl group. Then, specimens were measured surface roughness and processed for scanning electron microscopic observation.

The results of this study were as follows.

TiO₂ blast implant surface showed increased surface roughness 1.5 minute after treatment with Tetracycline-HCl. But, there were not significant differences in saline group after treatment.

Tetracycline-HCl group showed changed surface micro-morphology in SEM after 1.5 minute. There were not significant differences in saline group after treatment.

Between Tetracycline-HCl group and saline group, there were difference in surface roughness change and SEM micro-morphology.

Tetracycline-HCl have influence on TiO₂ blast implant surface.

In conclusion, the detoxification with 50mg/ml Tetracycline-HCl must be applied respectively with different time according to various implant surfaces.