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  • 标题:The effects of newly formed synthetic peptide on bone regeneration in rat calvarial defects
  • 本地全文:下载
  • 作者:Choi, Jung-Yoo ; Jung, Ui-Won ; Kim, Chang-Sung
  • 期刊名称:The Journal of the Korean Academy of Periodontology
  • 印刷版ISSN:0250-3352
  • 出版年度:2010
  • 卷号:40
  • 期号:1
  • 页码:11-18
  • DOI:10.5051/jpis.2010.40.1.11
  • 语种:English
  • 出版社:Korean Academy of Periodontology
  • 摘要:Purpose

    Significant interest has emerged in the design of cell scaffolds that incorporate peptide sequences that correspond to known signaling domains in extracellular matrix and bone morphogenetic protein. The purpose of this study was to evaluate the bone regenerative effects of the synthetic peptide in a critical-size rat calvarial defect model.

    Methods

    Eight millimeter diameter standardized, circular, transosseus defects created on the cranium of forty rats were implanted with synthetic peptide, collagen, or both synthetic peptide and collagen. No material was was implanted the control group. The healing of each group was evaluated histologically and histomorphometrically after 2- and 8-week healing intervals.

    Results

    Surgical implantation of the synthetic peptide and collagen resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. When the experimental groups were compared to each other, they showed a similar pattern of bone formation. The defect closure and new bone area were significantly different in synthetic peptide and collagen group at 8 weeks.

    Conclusions

    Concerning the advantages of biomaterials, synthetic peptide can be an effective biomaterial for damaged periodontal regeneration.

  • 关键词:bone regeneration; Collagen; Synthetic peptide
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