Sjögren's syndrome is a chronic autoimmune exocrinopathy that destroys salivary and lacrimal gland tissue. We report an unusual case of this disease in a 54-year-old woman who presented with multiple and bilateral parotid cystic masses. The multiple, small, bead-like cysts were clearly evident in the computed tomography sections in this patient, a visible reminder that this may be the initial presentation in a patient with Sjögren's syndrome. As the case illustrates, Sjögren's syndrome should be included in the differential diagnosis of multiple and bilateral cystic parotid lesions.