文章基本信息

标题：Polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene in Kawasaki disease
本地全文：下载
作者：Han, Mi Young
期刊名称：Korean Journal of Pediatrics
印刷版ISSN：1738-1061
出版年度：2007
卷号：50
期号：6
页码：570-575
DOI：10.3345/kjp.2007.50.6.570
语种：Korean
出版社：The Korean Pediatric Society
摘要：Purpose
To demonstrate genetic background of pathogenesis of Kawasaki disease (KD), I examined the genetic polymorphism of plasminogen activator inhibitor-1 (PAI-1) in KD patients.
Methods
PCR-RFLP of PAI- 1 promotor gene was analyzed in 56 KD patients admitted to Kyunghee University Hospital, Gachon Medical School Gil Hospital, and Eulji Hospital from March to August 2000 and 206 normal control populations.
Results
There were no differences in the genotype and allelic frequency of the PAI-1-675 (4G/5G) and PAI-1-844 (G/A) polymorphic site (which are located in the promoter region) between KD and control subjects. Also I could not detect any significant differences in specific genotypes between patients with the coronary artery lesion (CAL) and patients without CAL.
Conclusion
No association was observed in -844 G/A and -675 4G/5G of PAI-1 gene polymorphism with KD.
关键词：Kawasaki disease; Genetic Polymorphsm; Plasminogen activator inhibitor