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  • 标题:Testicular adrenal rest tumors in a patient with untreated congenital adrenal hyperplasia
  • 本地全文:下载
  • 作者:Jin, Hye Young ; Choi, Jin Ho ; Kim, Gu Hwan
  • 期刊名称:Korean Journal of Pediatrics
  • 印刷版ISSN:1738-1061
  • 出版年度:2011
  • 卷号:54
  • 期号:3
  • 页码:137-140
  • DOI:10.3345/kjp.2011.54.3.137
  • 语种:English
  • 出版社:The Korean Pediatric Society
  • 摘要:

    Testicular adrenal rest tumors (TARTs) are considered to be formed from aberrant adrenal tissue that has become hyperplastic because of elevated adrenocorticotropic hormone (ACTH) in male patients with congenital adrenal hyperplasia (CAH). A 6-year-old boy presented with testicular enlargement and pubic hair. He was diagnosed with CAH complicated by precocious puberty. However, he was not followed-up. At the age of 17, he visited the outpatient clinic because of testicular enlargement and short stature. His right and left testicles were 10×6 cm and 7.5×4.5 cm, respectively. His height was 155.1 cm (standard deviation score [SDS], -2.90). The diagnosis of CAH due to 21 hydroxylase deficiency was confirmed by mutation analysis of CYP21A2 . Histological examination of the testes showed large, polygonal, eosinophilic cells with round nuclei and prominent nucleoli, which were suggestive of TARTs. He was treated with dexamethasone for 3 weeks and tumors regressed. Subsequently, dexamethasone was replaced by prednisolone and 9α-fludrocortisone; thereafter, the reduced testis size has been maintained.

  • 关键词:Congenital adrenal hyperplasia; Testicular adrenal rest tumors; Precocious Puberty; Child
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