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  • 标题:A case of regression of atypical dense deposit disease without C3 deposition in a child
  • 本地全文:下载
  • 作者:Kim, Min Sun ; Hwang, Pyoung Han ; Kang, Mung Jae
  • 期刊名称:Korean Journal of Pediatrics
  • 印刷版ISSN:1738-1061
  • 出版年度:2010
  • 卷号:53
  • 期号:7
  • 页码:766-769
  • DOI:10.3345/kjp.2010.53.7.766
  • 语种:English
  • 出版社:The Korean Pediatric Society
  • 摘要:

    Dense deposit disease (DDD) is a rare disorder characterized by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidneys. The diagnosis is made in most patients between 5 and 15 years of age, and within 10 years, approximately half of the affected patients progress to end-stage renal disease. We report a rare case of regressive DDD without C3 deposition after steroid therapy in an 11-year-old boy. The patient presented with edema, gross hematuria, and nephrotic-range proteinuria. Laboratory testing revealed a serum creatinine level of 1.17 mg/dL, albumin level of 2.3 g/dL, and serum C3 level of 125 mg/dL (range 90-180 mg/dL). The results of the renal biopsy were consistent with DDD without C3 deposition. After 6 weeks of steroid therapy, the nephrotic syndrome completely resolved. The follow-up renal biopsy showed a significant reduction in mesangial proliferation and disappearance of electron-dense deposits in the GBM.

  • 关键词:Child; Glomerulonephritis; Membranoproliferative; Remission Induction
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