文章基本信息

标题：The Effect of Dorzolamide-Timolol and Latanoprost on Redox Cycle in Aqueous Humor of Rabbit
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作者：Park, Sang Woo ; Lee, Seung Hyun ; Mun, Gui Hyeong 等
期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2009
卷号：50
期号：3
页码：424-428
DOI：10.3341/jkos.2009.50.3.424
语种：Korean
出版社：The Korean Ophthalmological Society
摘要：Purpose
To evaluate the effect of dorzolamide-timolol and latanoprost on redox cycle of superoxide dismutase (SOD) and ascorbic acid in the aqueous humor of the rabbit.
Methods
Group 1 (20 eyes of 10 rabbits) was instilled with dorzolamide-timolol in the right eye and Group 2 (20 eyes of 10 rabbits) was instilled with latanoprost in the same manner. Four weeks after instillation, SOD activity and ascorbic acid concentration were analyzed.
Results
In Group 1, SOD activity and ascorbic acid concentration of the right eye and left eye were 15.7% and 19.3% ( p =0.27), 2.7 pM and 2.6 pM ( p =0.47), respectively. In Group 2, SOD activity and ascorbic acid concentration of the right and left eye were 22.3% and 27.6% ( p =0.14), 2.3 pM and 2.1 pM ( p =0.89), respectively.
Conclusions
There was no significant difference of SOD activity and ascorbic acid concentration between both eyes in Group 1 and 2.
关键词：Ascorbic Acid; Dorzolamide-timolol; Latanoprost; Superoxide dismutase