文章基本信息

标题：Analysis of Intraocular Cytokines According to Progression of Diabetic Retinopathy and Macular Edema in Diabetic Patients
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作者：Sin, Bum Ho ; Kim, Jin Young ; Park, Ji Young 等
期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2013
卷号：54
期号：4
页码：618-626
DOI：10.3341/jkos.2013.54.4.618
语种：Korean
出版社：The Korean Ophthalmological Society
摘要：Purpose
To investigate the relationship between the aqueous concentrations of cytokines, chemokine, VEGF and the severity of diabetic retinopathy and diabetic macular edema.
Methods
Sixty eyes with diabetic retinopathy and diabetic macular edema, and 10 eyes of nondiabetic subjects were followed for 6 months. The aqueous levels of inflammatory and anti-inflammatory factors were measured. The aqueous levels of cytokines were investigated according to the severity of diabetic retinopathy and diabetic macular edema.
Results
The aqueous levels of IL-6, IL-8, IL-10, MCP-1, and VEGF were elevated according to the severity of diabetic retinopathy. The aqueous levels of IL-13 were higher in eyes of diabetic patients than in eyes of nondiabetic subjects, but there were no statistically significant difference between diabetic retinopathy and nondiabetic subjects. The aqueous levels of IL-6, MCP-1, and VEGF were positively correlated with central macular thickness in eyes with diabetic macular edema.
Conclusions
The aqueous levels of IL-6, IL-8, IL-10, MCP-1, and VEGF were correlated with the severity of diabetic retinopathy. The aqueous levels of IL-6, MCP-1, and VEGF were positively correlated with the severity of macular edema.
关键词：Anterior chamber; Cytokines; Diabetic macular edema; Diabetic retinopathy; Vascular endothelial growth factor