文章基本信息

标题：Effect of Sodium Hyaluronate and Cyclosporine A on Tear Film in Dry Eye Syndrome
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作者：Chang, In Boem ; Park, Jung Hyun ; Kim, Moo Sang 等
期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2013
卷号：54
期号：2
页码：231-236
DOI：10.3341/jkos.2013.54.2.231
语种：Korean
出版社：The Korean Ophthalmological Society
摘要：Purpose
To evaluate the efficacy of topical 0.1% hyaluronate (HA) and 0.05% cyclosporine A on tear film parameters in dry eye syndrome patients.
Methods
Patients who were diagnosed with dry eye syndrome were treated with mbined with cyclosporine A (Group 2, 54 eyes). Ocular surface disease index (OSDI), tear film break-up time (BUT), Schirmer's test, and tear osmolarity were evaluated before treatment and at 1, 2, 3, and 6 months after treatment.
Results
OSDI was significantly improved at 2 months after treatment and Schirmer's test results significantly improved at 1 month after treatment in both groups. The BUT was significantly improved 3 months after treatment in Group 1 and at 1 month after treatment in Group 2. Tear osmolarity significantly improved at 1 month after treatment in both groups, but continuously improved up to 6 months after treatment only in Group 2. The BUT and Schirmer's test showed greater improvements in Group 2 than in Group 1.
Conclusions
Combined treatment of topical 0.1% HA and 0.05% cyclosporine A may be more effective for improving dry eye syndrome.
关键词：Cyclosporine; Dry eye syndrome; Restasis; Tear osmolarity