文章基本信息

标题：Decorin and TGF-β Expression after Partial Myotomy of the Extraocular Muscle in Rat
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作者：Lim, Young Jin ; Kim, Gyu Nam ; Lee, Na Eun 等
期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2013
卷号：54
期号：1
页码：143-148
DOI：10.3341/jkos.2013.54.1.143
语种：Korean
出版社：The Korean Ophthalmological Society
摘要：Purpose
To report the expression of decorin and TGF-β in partial myotomy of the extraocular muscle in rats.
Methods
Partial myotomy of the superior rectus muscle was performed on the right eye of 10 Sprague-Dawley rats followed by exposure of the left superior rectus muscle and a simple suture of the conjunctiva. The bilateral superior rectus muscle was obtained from all rats at 2 weeks postoperatively. The tissues were observed under light microscopy with hematoxylin-eosin, Masson's trichrome staining and immunohistochemistry.
Results
Histological examinations of the surgical area at 2 weeks after postoperatively showed irregularly concentrated fibrosis on light microscopy with hematoxylin-eosin and Masson's trichrome staining of the experimental eyes. Immnohistochemistry showed that expression of decorin was in the same location as TGF-β in the experimental group.
Conclusions
The expression of decorin was found in the healing process after partial myotomy of the extraocular muscle in rats. Immunohistochemistry showed that expression of decorin was in the same location as with TGF-β.
关键词：Decorin; Extraocular Muscle; Fibrosis; Tumor growth factor