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  • 标题:Long-term Evaluation After Topical Cyclosporine Treatment in Dry Eye Patients With Graft-Versus-Host Disease
  • 本地全文:下载
  • 作者:Lee, Seung Hyun ; Im, Seoung Kyu ; Woo, Je-Moon
  • 期刊名称:Journal of the Korean Ophthalmological Society
  • 印刷版ISSN:0378-6471
  • 出版年度:2009
  • 卷号:50
  • 期号:1
  • 页码:27-33
  • DOI:10.3341/jkos.2009.50.1.27
  • 语种:Korean
  • 出版社:The Korean Ophthalmological Society
  • 摘要:Purpose

    This study was performed to evaluate the long-term effect of 0.05% cyclosporine A emulsion (Restasis, Allergan Inc. USA.) on dry eye associated with graft-versus-host disease (GVHD).

    Methods

    Sixteen eyes of 8 patients with severe dry eye associated with GVHD were treated with 0.05% cyclosporine A emulsion twice a day. Tear film parameters were evaluated before treatment and after 1, 3, 6, and 12 months of treatment.

    Results

    One month after treatment, tear break-up time improved from 3.88±1.78 s to 4.17±1.90 s ( P =0.02). Three months after treatment, symptom score and basal secretion improved from 3.00±0.38 and 4.44±1.59 mm to 2.33±0.52 ( P =0.04) and 5.42±2.50 mm ( P =0.04), respectively. Twelve months after treatment, the keratoepitheliopathy score improved from 2.38±1.31 to 1.13±0.35 ( P =0.02).

    Conclusions

    Use of a 0.05% cyclosporine A emulsion is effective for dry eye associated with GVHD as it helps to increase tear secretion and to relieve symptoms. Treatment with 0.05% cyclosporine A emulsion for longer than 1 year may be necessary to improve keratoepitheliopathy.

  • 关键词:Cyclosporine; Dry eye syndrome; Graft-versus-host disease
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