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  • 标题:Photodynamic Therapy of Choroidal Neovascularization in Age-Related Macular Degeneration with Verteporfin: An Analysis of 10 Years of Clinical Results
  • 本地全文:下载
  • 作者:Cho, Doo Young ; Bae, So Hyun ; Han, Jae Ryong
  • 期刊名称:Journal of the Korean Ophthalmological Society
  • 印刷版ISSN:0378-6471
  • 出版年度:2012
  • 卷号:53
  • 期号:1
  • 页码:59-67
  • DOI:10.3341/jkos.2012.53.1.59
  • 语种:Korean
  • 出版社:The Korean Ophthalmological Society
  • 摘要:Purpose

    To analyze the long-term results of photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD).

    Methods

    The clinical data of patients treated with photodynamic therapy for exudative age-related macular degeneration between April 2000 and December 2000 were analyzed. Patients were followed-up for at least 10 years after PDT.

    Results

    Twenty-nine eyes of 29 patients were enrolled. Mean visual acuity on the logarithm of the minimum angle of resolution (log MAR) scale was 0.78 ± 0.34 at baseline, 1.01 ± 0.42 at 60 months, and 1.02 ± 0.41 at 120 months. Predominantly classic, minimally classic, and occult without classic choroidal neovascularization was noted in 51.7%, 17.2%, and 31.1% of patients, respectively. Visual acuity was improved by 1 or more lines in 27.6% of patients and was unchanged in 20.7% of patients, while 51.7% of patients had lost 1 or more lines of visual acuity by 120 months. Baseline visual acuity and age were associated with the final visual prognosis ( p < 0.05). Four patients developed neovascular AMD in the contralateral eye.

    Conclusions

    PDT is safe and effective for neovascular AMD. However, AMD can recur at any time and thus patients should be followed-up for a long period of time.

  • 关键词:Age-related macular degeneration (AMD); Choroidal neovascularization (CNV); Photodynamic therapy (PDT)
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