文章基本信息

标题：Analysis of Systemic Factors through Blood Examination in Normal-Tension Glaucoma Patients
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作者：Lee, Na Young ; Ahn, Myung Douk
期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2010
卷号：51
期号：2
页码：241-247
DOI：10.3341/jkos.2010.51.2.241
语种：Korean
出版社：The Korean Ophthalmological Society
摘要：Purpose
In this study, we evaluated systemic hemodynamic factors of normal tension glaucoma.
Methods
Forty patients with normal tension glaucoma and thirty healthy people were investigated with regard to hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, triglycerides, LDL, HDL, and high-sensitivity C-reactive protein (hsCRP). Also, ET-1 and MCP-1 were measured using enzyme-linked immunosorbent assay kits.
Results
The results of the blood examinations showed no statistically significant differences in hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, LDL, HDL, and hsCRP. Only triglycerides showed a statistically significant difference between the groups ( P =0.03). The level of serum ET-1 was significantly higher in the normal tension glaucoma group ( P =0.007). The results of MCP-1 showed no statistically significant difference.
Conclusions
We conclude that normal tension glaucoma Is associated with an increased level of triglycerides and that the level of ET-1 could be a hemodynamic cause of normal tension glaucoma.
关键词：Endothelin-1; Hemodynamic factors; High-Sensitivity C-reactive Protein; Macrophage chemoattractant protein-1; Normal tension glaucoma