文章基本信息

标题：Changes in hemodynamic parameters and regional myocardial perfusion measured by thermal diffusion probe from the infusion of norepinephrine during displacement of porcine beating heart
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作者：Lee, Jong Wha ; Bang, Sou Ouk ; Park, Han Ki 等
期刊名称：Korean Journal of Anesthesiology
印刷版ISSN：2005-6419
出版年度：2008
卷号：55
期号：4
页码：479-484
DOI：10.4097/kjae.2008.55.4.479
语种：Korean
出版社：The Korean Society of Anesthesiologists,
摘要：Background
This study was done to evaluate the sole effect of norepinephrine on the regional myocardial perfusion during displacement of the porcine beating heart using thermal diffusion method.
Methods
Thermal diffusion probe was inserted into the anterior myocardial wall during 20 procedures in 10 male pigs (30-35 kg). The measurements of regional myocardial perfusion and hemodynamic parameters were performed after complete instrumentation (baseline), after displacement of the beating heart anteriorly, and 5 and 15 minutes after norepinephrine infusion, titrated to restore baseline mean arterial pressure (MAP).
Results
Norepinephrine infusion reversed the decrease in MAP and myocardial perfusion, caused by displacement of the beating heart (62 ± 3% to 115 ± 4% of baseline, P < 0.01; 41 ± 5% to 125 ± 4% of baseline, P < 0.05, respectively).
Conclusions
Restoration of MAP with norepinephrine infusion without any preload augmentation reversed deterioration in regional myocardial perfusion during displacement of the porcine beating heart.
关键词：myocardial perfusion; norepinephrine; off-pump coronary artery bypass graft