文章基本信息

标题：Antinociceptive Effect of Intraperitoneally Administered 5,5-dimethyl-1-pyrroline N-oxide on Formalin Induced Nociception in Rats
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作者：Chung, Woo-suk ; Go, Young-gwon ; Lee, Won-hyung 等
期刊名称：Korean Journal of Anesthesiology
印刷版ISSN：2005-6419
出版年度：2008
卷号：54
期号：3
页码：S35-S39
DOI：10.4097/kjae.2008.54.3.S35
语种：English
出版社：The Korean Society of Anesthesiologists,
摘要：Background
Reactive oxygen species (ROS) is known to be involved in chronic and persistent pain. By using the ROS scavenger 5,5-dimethyl-1-pyrroline N-oxide (DMPO), we studied the effects of ROS on formalin-induced nociception in rats.
Methods
5% formalin was injected in the left hind paw after intraperitoneal injection of saline or various doses of DMPO (10 mg/kg, 30 mg/kg, 100 mg/kg). Number of flinches was measured in a 5 minute interval for 1 hour.
Results
Formalin injected into the left hind paw induced a biphasic nociceptive behaviour. Intraperitoneal injection of DMPO diminished nociceptive behaviors dose-dependently during phase 2 but not phase 1.
Conclusions
ROS might be involved in central sensitization and DMPO, a ROS scavenger, posses antinociceptive property in rats subjected to formalin induced hyperalgesia.
关键词：DMPO; formalin test; ROS