文章基本信息

标题：Fetal congenital malformations associated with letrozole use for anovulatory infertility
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作者：Rusva A. Mistry ; Anil Singh ; Bipin Nayak 等
期刊名称：Journal of Clinical & Experimental Research
印刷版ISSN：2320-348X
电子版ISSN：2320-3811
出版年度：2014
卷号：2
期号：1
页码：99-102
DOI：10.5455/jcer.201416
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出版社：International Medical Journal Management and Indexing System
摘要：There are no published case reports of letrozole (an aromatase inhibitor) induced neurological deficit with skeletal congenital malformations in a newborn born to mother taking letrozole for primary anovulatory infertility, here we report such a case. Patient had taken treatment with tablet letrozole 2.5mg from 2nd day of menses for 5 days for such 3 cycles in government hospital. Before that patient was already given such 6 cycles from private hospital, but patient didnot give that history initially when asked before prescribing letrozole in government hospital. Regular followups by ultrasonography (USG) were done since starting of treatment, USG report at 4 months & 10 days of completion of therapy showed congenital malformations in male fetus and so termination of pregnancy was advised. As per Naranjos causality assessment, it falls in a Probable adverse drug reaction.
关键词：Congenital malformations; infertility; letrozole