文章基本信息

标题：Luteal transdermal estrogen supplementation in patients with polycystic ovarian syndrome undergoing in vitro fertilization treatment: A prospective randomized controlled study
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作者：Gulnur Ciftci ; Suna Ozdemir ; Kazim Gezginc 等
期刊名称：Balkan Military Medical Review
电子版ISSN：1107-6275
出版年度：2010
卷号：13
期号：4
页码：151-156
语种：
出版社：International Medical Journal Management and Indexing System
摘要：The aim of this study is to investigate the effectiveness of transdermal E2 supplementation in the luteal phase of the patients with polycystic ovarian syndrome (PCOS) undergoing IVF treat- ment. The present study was a prospective, single- centre, randomized, controlled, group-compara- tive clinical trial assessing E2 supplementation during luteal phase in PCOS women undergoing ICSI-ET. Patients were randomized into the study group (n=45) received E2 supplementation in the form of transdermal patches (100 ?g/day) twice per week starting the following night after oocyte retrieval. Patients were randomized to the control group (n=46) received no E2 supplementation. Luteal phase support was in the form of 50 mg IM progesterone. There were no significant differ- ences in the implantation (21.5% vs. 30%), clinical pregnancy (19/45 [42.2%] vs. 24/46 [52.1%]; p=0.43), and ongoing pregnancy rates (16/45 [35.5%] vs. 21/46 [45.6%]; p=0.29) between the study and control groups, respectively. Early preg- nancy loss and multiple pregnancy rates were (3/19 [15.7%] vs. 3/24 [12.5%]; p=0.82) (4/19 [21%] vs 5/24 [20.8%]; p=0.39) in study and control groups, respectively. The addition of transdremal E2 sup- plementation to the luteal phase P support of IVF cycles does not improve cycle outcomes in regard to implantation and pregnancy rates in PCOS patients.
关键词：Luteal phase support; Estradiol sup- plementation; Polycystic ovarian syndrome; Pregnancy rate.