Rheumatoid Arthritis is the most common, chronic autoimmune disease with no known cure, and a priority for biological research in the twenty first century. The limitations in the efficacy and safety of current treatment strategies are driving the need for new, safe and effective medications. Recent experimental findings focus on the potential of neutraceuticals for the management of rheumatoid arthritis. In this review, we summarize the effect of several dietary phytochemicals against RA with important biochemical findings. A number of dietary phytochemicals can either retard or improve the RA by their anti-oxidative, anti-inflammatory, immunomodulatory and enzyme inhibitory effects. This review suggests that the dietary phytochemicals have immense potential, to be developed as safe and effective treatment options. More research is required to understand how dietary phytochemicals affect rheumatoid arthritis.