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标题：Correlation between expressions of Cyclin-D1, \{EGFR\} and p53 with chemoradiation response in patients of locally advanced oral squamous cell carcinoma
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作者：Huma Khan ; Seema Gupta ; Nuzhat Husain 等
期刊名称：BBA Clinical
印刷版ISSN：2214-6474
出版年度：2015
卷号：3
页码：11-17
DOI：10.1016/j.bbacli.2014.11.004
出版社：Elsevier B.V.
摘要：AbstractIntroduction Cyclin-D1, p53 and \{EGFR\} are molecular markers that regulate the cell cycle and play an important role in tumor progression and development. The present study evaluates the prognostic significance of these markers with chemoradiation response in patients of locally advanced oral squamous cell carcinoma (OSCC). Material and method A total of 97 \{OSCC\} patients (females = 19 and males = 78), aged 20–67 years and stage III/IV were recruited. Treatment response was assessed according to \{WHO\} criteria. Cyclin-D1, p53 and \{EGFR\} expressions in tumor tissue was estimated by immunohistochemical (IHC) method and quantified as percentage positive nuclei. Results The positive expression rates of molecular markers were 86.6% for Cyclin-D1, 92.8% for \{EGFR\} and 85.6% for p53. The strong positive expressions of both Cyclin-D1 and p53 showed significant association with poor response. The Cox multivariate regression analysis showed coexpressions of Cyclin-D1 and p53 a significant and independent predictor of overall survival (OR = 1.90, 95% CI = 1.45–4.82, p = 0.046) after adjusting the demographic, clinicopathological and radiological response. The strong positive expressions of Cyclin-D1 and p53 and coexpressions of Cyclin-D1, \{EGFR\} and p53 showed significant (p < 0.05 or p < 0.01 or p < 0.001) and lower survival as compared to negative or moderate positive expressions and coexpressions, respectively. Conclusion Expressions and coexpressions of Cyclin-D1 and p53 may serve as a prognostic marker in \{OSCC\} patients.
关键词：Cyclin-D1 ;\{EGFR\} ;p53 Immunohistochemistry ;Squamous cell carcinoma ;Chemoradiation